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  • Deprecated function: Return type of DateObject::__wakeup() should either be compatible with DateTime::__wakeup(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in include_once() (line 158 of /var/www/ee.old.uth.gr/sites/all/modules/date/date_api/date_api.module).
  • Deprecated function: Return type of DateObject::format($format, $force = false) should either be compatible with DateTime::format(string $format): string, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in include_once() (line 158 of /var/www/ee.old.uth.gr/sites/all/modules/date/date_api/date_api.module).
  • Deprecated function: Return type of DateObject::setTimezone($tz, $force = false) should either be compatible with DateTime::setTimezone(DateTimeZone $timezone): DateTime, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in include_once() (line 158 of /var/www/ee.old.uth.gr/sites/all/modules/date/date_api/date_api.module).
  • Deprecated function: Return type of DBObject::current() should either be compatible with Iterator::current(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 7 of /var/www/ee.old.uth.gr/sites/all/modules/eck/eck.classes.inc).
  • Deprecated function: Return type of DBObject::next() should either be compatible with Iterator::next(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 7 of /var/www/ee.old.uth.gr/sites/all/modules/eck/eck.classes.inc).
  • Deprecated function: Return type of DBObject::key() should either be compatible with Iterator::key(): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 7 of /var/www/ee.old.uth.gr/sites/all/modules/eck/eck.classes.inc).
  • Deprecated function: Return type of DBObject::valid() should either be compatible with Iterator::valid(): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 7 of /var/www/ee.old.uth.gr/sites/all/modules/eck/eck.classes.inc).
  • Deprecated function: Return type of DBObject::rewind() should either be compatible with Iterator::rewind(): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in require_once() (line 7 of /var/www/ee.old.uth.gr/sites/all/modules/eck/eck.classes.inc).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in _filter_url_trim() (line 1664 of /var/www/ee.old.uth.gr/modules/filter/filter.module).
  • Deprecated function: strpos(): Passing null to parameter #1 ($haystack) of type string is deprecated in url_is_external() (line 2393 of /var/www/ee.old.uth.gr/includes/common.inc).
  • Deprecated function: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in url_is_external() (line 2395 of /var/www/ee.old.uth.gr/includes/common.inc).
  • Deprecated function: ltrim(): Passing null to parameter #1 ($string) of type string is deprecated in url() (line 2311 of /var/www/ee.old.uth.gr/includes/common.inc).

Structural and Functional Biochemistry

E-mail: 

ddleonidas@bio.uth.gr

Webpage: 

http://www.bio.uth.gr/index.php?option=com_content&view=article&id=193%3Alab-bio-7&catid=52%3Areslabs&Itemid=72&lang=el

Department: 

  • Department of Biochemistry and Biotechnology

Tel.: 

+30 2410 565297

Research Categories: 

  • Biochemical Analysis
  • X-Ray Spectroscopy
  • Chromatographic Analysis
  • Immunochemistry
  • Enzymology
  • Nucleic Acids
  • Proteins
  • Physical Biochemistry
  • Clinical Chemistry

The Structural and Functional Biochemistry Laboratory serves the educational and research needs in the disciplines of biochemistry (intermediate metabolism, synthesis and nucleic acid metabolism, synthesis, structure and function of proteins), structural biochemistry, proteomics, structural genomics, regulation and Metabolic Control of Enzymes and the implementation of all the above in Analytical Biochemistry, Enzymology Clinical Biochemistry, Food biochemistry, Chemical Biology, structure-driven drug design and Biophysics as applied to Biochemical Sciences.

Research Activities: 

Control of Glycogen Metabolism.

Elucidation of the control, diversity and biological functions of deadenylases.

Structure-based design of enzyme inhibitors.

Structural basis of carbohydrate recognition by lectins.

Characterization and function of the mitochondrial steroid hormone receptors. Mechanisms of intracellular trafficking.

Molecular Modeling.

Research Projects: 

University of Thessaly Research Committee. "Proteomic analysis of the entomopathogeny of Pseudomonas entomophila". Grant No. 4098. PI: Μ.Κοntou.

University of Thessaly Research Committee. "Studies on function and structure of poly(A) specific ribonuclease, PARN". Grant No. 3743. PI: Nikolaos Balatsos.

Ministry of National Education and Religion Affairs Project Eraklitos IΙ: «Τranscriptomic and proteomic analysis of the most important parasite of the olive, the insect Bactrocera oleae, with emphasis on systems gender segregation and resistance to insecticides». M.Κοntou, collaborator.

University of Thessaly Research Committee. "Structure and function studies of the poly(A) specific ribonuclease PARN". Grant No.3743. PI: Nikolaos Balatsos.

University of Thessaly Research Committee. "Role of steroid hormone receptors in mitochondria functions" Grant No. 4088.14.01. PI: Α.–Μ. Psarra.

General Secretariat for Research and Technology, Joint Research Projects Greece – France (2010–2012): Human angiogenin as a molecular target for the development of new anticancer agents. PI: D.D. Leonidas.

ARISTEIA, Structure–assisted Design, Synthesis, and Evaluation of Bioactive compounds for type 2 Diabetes mellitus, PI: D.D. Leonidas.

Laboratory Infrastructure: 

Two Fast Protein Liquid Chromatography Systems (FPLC).

Nano-robot for protein crystallization.

Two-dimensional Electophoresis System.

ELISA plate reader.

Speed-vac.

γ-Counter.

Micro-equipment (electrophoresis, centrifuges etc).

Research Results / Products: 

Structure based design and biochemical evaluation of new hypoglycaemic agents.

Structure based design and assessment of new anti-inflammatory, and anti-cancer agents.

ΌνομαΕπίθετοIδιότητα - ΘέσηΤηλέφωνο
Leonidas
Demetres
Director
+30 2410 565278
Maria
Kontou
Assistant Professor
+30 2410 565281
Nikos
Balatsos
Assistant Professor
+30 2410 565261
George
Papadopoulos
Assistant Professor
+30 2410 565249
Anna–Maria
Psarra
Assistant Professor
+30 2410 565221
Vasiliki
Skamnaki
Senior Researcher
+30 2410 565281
Anastassia
Katsandi
Researcher
+30 2410 565297
Demetra
Hatzileontiadou
Researcher
+30 2410 565297
Athanasios
Kiritsis
Researcher
+30 2410 565297
Byron
Gorgogietas
Researcher
+30 2410 565297

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Γραμματεία Επιτροπής Ερευνών Πανεπιστημίου Θεσσαλίας

Γιαννιτσών & Λαχανά, Παλαιά - Συγκρότημα Τσαλαπάτα, 38334 - Βόλος

  • Τηλ: 24210 06414, Φαξ: 24210 06464

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